本文件描述了采用气相色谱法，测定口腔清洁护理液中乙醇与甲醇含量的方法，包括原理、试剂、仪器和设备、分析步骤、结果计算、检出限和定量限、回收率、精密度、允许差。
本文件适用于采用气相色谱分离，氢火焰离子化法测定口腔清洁护理液中甲醇和乙醇含量。
浩瀚色谱（山东）应用技术开发有限公司建立了以溶液为提取溶剂，应用气相色谱同步测定漱口水中甲醇和乙醇含量的分析方法。在超声条件下，使用提取漱口水中的甲醇和乙醇，提取液经HH-624(30 m×0.32 mm，1.8 μm)毛细管色谱柱分离，利用氢火焰离子化检测器(FID检测器)进行测定。在流量1.0 mL/min，分流比10∶1，FID检测器温度250 ℃条件下，漱口水中甲醇与乙醇可以得到良好分离，峰形较好。方法的线性相关性均大于0.999；精密度RSD(n=6)为1.7%～3.3%，回收率为92.4%～103.8%；检出限均为5 mg/kg。该方法简便快捷，灵敏度较高，适用于漱口水中甲醇和乙醇含量的测定。
名称：毛细管柱
规格：30 m×0.32 mm，1.8 μm
型号：HH-624
应用：QB/T 5703-2022 口腔清洁护理用品 口腔清洁护理液中乙醇和甲醇含量的检测方法 气相色谱法
This document describes a method for determining the content of ethanol and methanol in oral cleaning and care solutions using gas chromatography, including principles, reagents, instruments and equipment, analysis steps, result calculation, detection and quantification limits, recovery rate, precision, and allowable deviation.
This document is applicable to the determination of methanol and ethanol content in oral cleaning and care solutions using gas chromatography separation and hydrogen flame ionization method.
Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. has established an analytical method for simultaneous determination of methanol and ethanol content in mouthwash water using gas chromatography with solution as the extraction solvent. Under ultrasound conditions, methanol and ethanol were extracted from mouthwash, and the extraction solution was passed through HH-624 (30 m) × 0.32 mm, 1.8 μ m) Capillary chromatography column separation and determination using a hydrogen flame ionization detector (FID detector). Under the conditions of a flow rate of 1.0 mL/min, a split ratio of 10:1, and a FID detector temperature of 250 ℃, methanol and ethanol in mouthwash can be well separated with a good peak shape. The linear correlation of the methods is greater than 0.999; The precision RSD (n=6) is 1.7% to 3.3%, and the recovery rate is 92.4% to 103.8%; The detection limit is all 5 mg/kg. This method is simple, fast, and highly sensitive, suitable for the determination of methanol and ethanol content in mouthwash water.
Name: Capillary Column
Specification: 30 m × 0.32 mm, 1.8 μ M
Model: HH-624
Application: QB/T 5703-2022 Oral cleaning and care products - Detection method for ethanol and methanol content in oral cleaning and care solutions - Gas chromatography method
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